Researchers have modified an oncolytic virus so that it blocks the protein TGF-beta, helping expose tumors to the immune system.
Aptamer-facilitated Protection of Oncolytic Virus from Neutralizing Antibodies: Molecular Therapy - Nucleic Acids
Cancers, Free Full-Text
Viruses, Free Full-Text
Cutting both ways: the innate immune response to oncolytic virotherapy
Cancers, Free Full-Text
Enhancing anti-tumour efficacy with immunotherapy combinations - The Lancet
Oncolytic virotherapy using neural stem cells as a novel treatment option for glioblastoma multiforme - Ahmed - 2023 - MedComm – Oncology - Wiley Online Library
Oncolytic virus-driven immune remodeling revealed in mouse medulloblastomas at single cell resolution: Molecular Therapy - Oncolytics
Transgenic viral expression of PH-20, IL-12, and sPD1-Fc enhances immune cell infiltration and anti-tumor efficacy of an oncolytic virus: Molecular Therapy - Oncolytics
Improving cancer immunotherapy by rationally combining oncolytic virus with modulators targeting key signaling pathways, Molecular Cancer
Oncolytic Viruses: Therapeutics With an Identity Crisis - eBioMedicine
Doxorubicin Conjugation to Reovirus Improves Oncolytic Efficacy in Triple-Negative Breast Cancer - ScienceDirect
A new strategy for treating colorectal cancer: Regulating the influence of intestinal flora and oncolytic virus on interferon: Molecular Therapy - Oncolytics
National Cancer Institute on Instagram: One of the most important findings in cancer research in the past two decades is that tumors can create force-field-like protection against the immune system. A new
Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer: Molecular Therapy - Oncolytics